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Updated: Jul 4, 2025

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
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IL-15复合诱导的IL-10增强了原菌特异性的CD4+T毛囊辅助体差异化和抗体生产

Morgan Bravo1, Thamotharampillai Dileepan2, Molly Dolan1

  • 1Hennepin Healthcare Research Institute, Minneapolis, MN.

Journal of immunology (Baltimore, Md. : 1950)
|February 2, 2024
PubMed
概括

干白素-15复合体 (IL-15C) 治疗通过促进T毛囊辅助细胞 (Tfh) 分化和抗体产生来保护疟疾. 这种方法调节炎症,改善了感染Plasmodium的生存率.

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T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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