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Updated: Jul 4, 2025

Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale
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利用库林E3联酶适配蛋白SKP1进行向蛋白质降解

Seong Ho Hong1,2, Anand Divakaran1,2, Akane Osa1,2

  • 1Department of Chemistry, University of California, Berkeley, 2151 Berkeley Way, Room 312G, Berkeley, California 94720, United States.

ACS chemical biology
|February 2, 2024
PubMed
概括

研究人员开发了一种使用蛋白质溶解向嵌合体 (PROTACs) 进行向蛋白质降解的新方法. 这种方法利用SKP1蛋白来降解引起疾病的蛋白质,如BRD4和雄激素受体,提供了一种新的治疗策略.

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