评估低前置切除综合征的严重程度,在超低直肠癌的 intersphincteric 切除后:使用探索仪器的试点研究
Bin Zhang1, Guang-Zuan Zhuo1, Fei-Fan Liu1,2
1Department of Colorectal Surgery, The Characteristic Medical Center of PLA Rocket Force, Beijing, China.
Diseases of the colon and rectum
|February 2, 2024
概括
这项研究开发了一种探索性评分工具,用于在超低直肠癌手术后评估低前切除综合征 (LARS). 该工具与生活质量有显著的相关性,有助于全面评估LARS.
科学领域:
- 结肠直肠手术 结肠直肠手术
- 在瘤学瘤学.
- 患者报告的结果
背景情况:
- 低前切除综合征 (LARS) 显著影响直肠癌手术后的生活质量.
- 德尔菲共识确定了对定义LARS至关重要的关键症状和后果.
- 标准化对LARS的评估仍然是一个挑战,需要开发精确的评分仪器.
研究的目的:
- 为LARS.开发和描述一个探索性评分仪器.
- 为了将德尔菲共识的优先事项与功能和生活质量得分联系起来.
- 对超低直肠癌进行间切除后LARS的评估.
主要方法:
- 一项前性试点研究,涉及137名患者,这些患者经过间切除和骨髓切除术逆转.
- 使用基于韦克斯纳失禁分数的5分频率尺度 (0-4).
- 通过在多个随访点进行电子调查,收集患者报告的关于症状/后果严重程度和生活质量的数据.
主要成果:
- "清空困难"和"对肠道不满"是LARS最常见的问题.
- 一种探索仪器和便失禁生活质量表显示出显著的改善 (分别为p=0.009和p=0.04).
- 患者报告的生活质量与德尔菲共识严重性得分 (rs = -0.73) 有很强的相关性.
结论:
- 基于德尔菲共识优先事项开发的评分工具提供了对LARS评估的综合方法.
- 这种工具可能会改善对超低直肠癌的脊髓间切除后LARS的评估.
- 由于单个机构的数据和有限的样本规模,在更大,多机构的研究中需要进一步验证.
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