肌肉发育不良症中的心血管磁共振:展望未来
Ana Filipa Amador1, Teresa Pinho1, Catarina Martins da Costa1
1Department of Cardiology, São João University Hospital Center, Porto; Faculty of Medicine, University of Porto.
概括
心脏磁共振 (CMR) 有效地预测肌肉衰竭 (MuD) 患者的心脏事件. 在CMR上减少左心室射出分数 (LVEF) 和晚期加多增强 (LGE) 是MuD中心脏不良事件的关键指标.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 心脏磁共振 (CMR) 对心肌病风险分层至关重要.
- 它在肌肉发育不良 (MuD) 的实用性需要进一步调查.
研究的目的:
- 为了评估CMR在预测心脏事件中的表现,在一个队列的MuD患者.
- 确定CMR衍生的参数,与MuD中不良心脏结果相关.
主要方法:
- 对接受心脏查 (2012-2018) 的成人MuD患者进行前性,单中心研究.
- 收集了临床数据和CMR参数,包括左心室喷射分数 (LVEF) 和晚期加多增强 (LGE).
- 在随访期间,主要心脏不良事件 (MACE) 被跟踪.
主要成果:
- 在65名MuD患者中,43.3%的CMR发现异常,包括7名LVEF<55%和23名LGE.
- 在77个月的中位数随访期间,发生了7例死亡,8例装置植入和1例持续的腹腔心动减速.
- 无论是LVEF<55% (aHR 4.81) 和LGE存在都与MACE有显著的关联.
结论:
- 慢性心血管回血率 (CMR) LVEF <55%和LGE存在是 MuD患者心脏不良事件的显著预测因素.
- 这些CMR发现增强了MuD群体的风险分层能力.
- 在肌肉发育不良症中,CMR在控制心脏并发症方面发挥着至关重要的作用.
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