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血清代谢和肠道微生物组的改变与老年人手握强度低相关
Yan Guo1,2, Qin Wang1,3, Yifan Lv1
1Department of Geriatrics, Division of Geriatric Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.
老年人手握力下降与改变的肠道微生物群代谢物,特别是酸衍生物有关. 这些发现可能有助于识别肌肉力量丧失的生物标志物.
科学领域:
- 老年学是指老年学的学科.
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 手握强度 (HGS) 是老年人健康,残疾和死亡率的关键指标.
- 低HGS与肉症和身体虚弱有关,需要对其潜在机制进行研究.
- 了解与HGS下降相关的代谢因素对于开发干预措施至关重要.
研究的目的:
- 研究与老年人降低HGS相关的代谢机制和潜在生物标志物.
- 探索血清和便代谢物,肠道微生物组合和HGS之间的关系.
- 为了识别与肌肉力量下降相关的特定代谢物和微生物特征.
主要方法:
- 使用液态染色体质谱法 (LC-MS) 分析血清和便代谢组.
- 测序16S核糖体DNA (rDNA) 以表征肠道微生物组合.
- 斯皮尔曼的相关性分析将代谢物和微生物数据与HGS水平联系起来.
主要成果:
- 在低HGS的个体中观察到较低的碳酸和衍生物水平.
- 血清中甲基糖氨酸,4 - 甲基胺酸和 (e) -3,4,5-三甲基胺酸的水平与HGS正相关.
- 低HGS组表现出更高的肠道微生物α-多样性,而正常HGS组显示出更高的β-多样性. 在低HGS组中,Parabacteroides*和*Intestinibacter*的属性升高.
结论:
- 特定的肉酸衍生物的水平变化和肠道微生物的转变与老年人减少HGS有关.
- 这些发现表明潜在的代谢途径和微生物生物标志物有助于肌肉力量的下降.
- 进一步的研究可以利用这些见解来早期检测和管理肉症和脆弱性.
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