在非痴呆症患者中,口头表达语言受到最小的影响,这些人生活在患有肌缩侧面硬化症的人中
Elisabeth Kasper1,2, Anna G M Temp2,3, Verena Köckritz2
1Department of Neurology, University Medical Centre, Rostock, Germany.
Amyotrophic lateral sclerosis & frontotemporal degeneration
|February 2, 2024
概括
肌缩侧面硬化症 (ALS) 患者没有显著的口头表达语言障碍,与此前的研究相反. 语音不流是唯一注意到的缺陷,受认知状态和失联症的影响.
科学领域:
- 神经学 神经学
- 语言学的语言学.
- 认知科学 认知科学
背景情况:
- 语言功能障碍是肌缩侧面硬化症 (ALS) 中常见的认知缺陷.
- 对日常功能至关重要的口头表达语言在ALS中缺乏研究,尽管有普遍的言论障碍的证据.
研究的目的:
- 与健康对照组 (HC) 相比,研究ALS (plwALS) 患者的口头表达语言.
- 在plwALS中分析话语的生产力,内容,语法复杂性,语音流性和动词处理.
主要方法:
- 64个plwALS和49个HC描述了饼干盗窃图片任务.
- 分析包括话语生产力,内容,语法,流利性和动词处理.
- 贝叶斯假设测试包含了失节症,认知障碍状态 (CIS) 和口头智商.
主要成果:
- 与HC相比,plwALS仅表现出语音不流利;其他语言措施不受影响.
- 认知和失联症显著影响了词数和内容密度,而不是口头智商.
- 仅仅是认知障碍就解释了不流;身体代理动词的产生率更高.
结论:
- 与现有文献相反,这项研究发现ALS没有明显的口头表达语言障碍.
- 发病症,认知障碍状态和口头智商是影响ALS中自发口头表达的关键变量.
- 较小的表达性语言缺陷与执行功能障碍和脱节症比主要语言障碍更相关.
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