生物模拟响应纳米转换器与免疫检查点阻塞加上抗血管生成用于高级肝细胞癌治疗
Yuting Zhang1,2, Aoxue Zhong2, Juan Min3
1Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, P. R. China.
ACS applied materials & interfaces
|February 2, 2024
概括
一种新型纳米药物将血管生成抑制剂的向输送与免疫检查点阻塞相结合,通过减少瘤负担和转移而减少瘤负担和转移,显著改善晚期肝癌 (HCC) 模型的结果.
科学领域:
- 在瘤学瘤学.
- 纳米医学是一种纳米医学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 晚期肝细胞癌 (HCC) 治疗结合了免疫检查点抑制剂和抗血管生成剂.
- 目前的治疗方法面临的局限性包括严格的标准,副作用和因系统性药物输送而导致的低于最佳反应.
研究的目的:
- 开发一种单剂智能纳米药物来治疗先进的HCC.
- 模仿治疗计划,增强生物相容性,并引起强大的抗瘤免疫力.
主要方法:
- 使用pH响应的多乙烯甘醇-多β-氨基 (PEG-PAE) 纳米载体来输送阿帕蒂尼布 (血管生成抑制剂).
- 表面涂层的纳米载体与来自过度表达PD-1蛋白质以阻断PD-L1 (免疫检查点抑制剂) 的细胞的等离子膜.
- 在先进的HCC小鼠模型中进行了测试,并进行了转移.
主要成果:
- 实现显著的瘤回归 (5/9) 和肝功能恢复.
- 证明了肺转移的完全抑制.
- 在瘤微环境中观察到免疫效应细胞 (CD8 +,CD4 + T细胞) 的增加和免疫抑制细胞 (MDSC,Tregs) 的减少.
- 在大型HCC瘤 (>50%肝体积) 中选择性积累的纳米药物,系统性副作用最小.
结论:
- 多功能纳米转换器有效地重塑了瘤微环境.
- 这种方法显示了治疗高级HCC的潜力,提高了疗效和降低了毒性.
相关概念视频
01:27Tumor Immunotherapy
526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K