激素治疗是否会影响前列腺癌患者的认知能力? 一个系统的审查和元分析
Antoine Boué1, Florence Joly1,2,3, Justine Lequesne2,3
1INSERM 1086 Anticipe, UniCaen, Normandie University, Caen, France.
Cancer
|February 2, 2024
概括
前列腺癌的激素治疗可能会增加认知困难,但这次系统性审查没有发现客观认知表现下降的确证据. 需要进一步的研究来了解这些影响.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
背景情况:
- 激素治疗是一种常见的前列腺癌治疗方法.
- 认知障碍是潜在的副作用,影响老年患者的自主权.
- 之前关于激素治疗对认知效应的研究产生了相互矛盾的结果.
研究的目的:
- 系统地审查和元分析激素治疗对前列腺癌患者客观和主观认知的纵向影响.
- 综合现有证据,更清楚地了解治疗期间的认知变化.
主要方法:
- 在PubMed,Web of Science和PsycINFO进行了全面的文献搜索.
- 包括在内的研究是纵向评估接受雄激素缺乏治疗 (ADT) 和新一代激素治疗的患者的认知能力.
- 一项元分析将得分汇总成六个客观和一个主观认知领域,使用随机效应模型计算效应大小.
主要成果:
- 20项研究 (1,440名患者) 纳入了审查;15 (1093名患者) 在分析中.
- 在ADT和新一代激素疗法 (g = -0.44, p = .03) 中观察到主观认知显著下降.
- 没有发现客观认知的显著下降,所有领域的影响大小都很小 (g = -0.02至0.18). 在客观认知领域中发现了显著的异质性.
结论:
- 这一元分析提供了证据,表明ADT和新一代激素疗法对主观认知有负面影响.
- 没有确的证据表明激素治疗期间客观认知能力下降.
- 客观认知研究中的高度异质性强调了前列腺癌研究中需要标准化的方法.
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