对于心血管风险评估来说,介质素-6和高灵敏性C反应蛋白的比较:MESA研究的发现
João Pedro Ferreira1, Francisco Vasques-Nóvoa2, João Sérgio Neves2
1UnIC@RISE, Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal; Centre d'Investigations Cliniques Plurithématique 1433, INSERM, Université de Lorraine, Nancy, France.
介质素-6 (IL6) 与心血管事件和死亡率的关联比高灵敏度C反应蛋白 (hsCRP) 更强. 这一发现表明IL6可能是评估无症状人群心血管风险的更有效生物标志物.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 炎症研究 炎症研究
背景情况:
- 炎症是主要心血管不良事件 (MACE) 的已知危险因素.
- 高灵敏度C反应蛋白 (hsCRP) 和互白素-6 (IL6) 的高水平与MACE有关.
- 对IL6和hsCRP进行心血管风险评估的比较研究有限.
研究的目的:
- 为了比较IL6和hsCRP在评估心血管风险中的有效性.
- 调查IL6和hsCRP与MACE在动脉样硬化多民族研究 (MESA) 队列中的关联.
主要方法:
- 根据IL6和hsCRP水平的中位数 (低-低,高-低,低-高,高-高) 将参与者分为四组.
- 分析了IL6,hsCRP和MACE之间的关联,平均随访时间为14年.
- 评估IL6和hsCRP对弗雷明汉风险评分的影响.
主要成果:
- IL6和hsCRP显示了适度的相关性 (Rho = 0.53).
- 独立于hsCRP的IL6升高显著与MACE,心力衰竭和死亡率的风险增加有关.
- 在对IL6进行调整后,hsCRP与MACE的关联失去了统计意义,而在对hsCRP进行调整后,IL6的关联仍然显著.
结论:
- 与hsCRP相比,IL6在多样化,无症状的人群中与动脉样硬化,心力衰竭和致命结局有更强的关联.
- 与hsCRP相比,IL6可能是心血管风险分层的更强大的生物标志物.
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