布普伦诺芬移动药物坚持平台 (MAP4BUP):一期可行性,可用性和疗效试点随机临床试验
Sterling M McPherson1, Crystal L Smith1, Luke Hall1
1Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, United States; Analytics and PsychoPharmacology Laboratory (APPL), Washington State University, Spokane, WA, United States; Program of Excellence in Addiction Research (PEAR), Washington State University, Spokane, WA, United States.
Drug and alcohol dependence
|February 2, 2024
概括
蓝牙药片盖和应用程序改善了阿片类药物使用障碍患者的药物坚持. 该装置是可行的和可用的,在干预组中显示了更高的药丸开口.
科学领域:
- 药理学 药理学是指药理学的学科.
- 数字健康数字健康
- 成 药物 药物 药物 药物
背景情况:
- 药物坚持不良是有效治疗阿片类药物使用障碍的布普伦诺芬/纳洛 (BUP/NAL) 的重要障碍.
- 优化坚持对于BUP/NAL治疗的长期成功至关重要.
研究的目的:
- 评估一个支持蓝牙的药片盖和移动应用程序的可行性和可用性,以提高BUP/NAL的坚持.
- 评估这个数字工具对阿片类药物使用障碍患者药物坚持的影响.
主要方法:
- 一个为期12周的试点随机临床试验,涉及41名接受BUP/NAL.的参与者.
- 参与者被随机分配到蓝牙药片盖设备 (PLY组) 或通常的标准服务 (SAU组) 带无活跃盖.
- PLY组收到文本/语音提醒,并从指定"助手"获得支持,以监控药囊使用情况.
主要成果:
- 蓝牙药片盖设备被发现是可行的 (92.86%) 和可用的 (78.57%) 在PLY组的大多数参与者.
- 虽然在统计学上不显著,但在PLY组 (84%) 与SAU组 (75%) 相比,药物坚持率更高.
- 药片盖的开口,一个依赖的指标,在PLY组 (平均91.8) 与SAU组 (平均56.7,p <0.05) 中显著更高.
结论:
- 蓝牙平板电脑帽和移动应用程序展示了可行性,可用性和高用户满意度.
- 这种干预与增加药物获取相关,以显著更高的药片盖开口为准.
- 这种数字坚持工具显示了改善阿片类药物使用障碍BUP/NAL治疗结果的希望.
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