预康复试验中的结果异质性 - 我们在比较果和子吗?
Wilson Jiang1, Kilian G M Brown2, Cherry Koh3
1Surgical Outcomes Research Centre (SOuRCe), Camperdown, NSW, Australia.
The Journal of surgical research
|February 2, 2024
概括
癌症手术预康复试验报告结果不一致,报告质量差. 制定标准化结果集对于改善预康复干预措施的研究和临床使用至关重要.
科学领域:
- 在瘤学瘤学.
- 手术研究的研究.
- 基于证据的医学基于证据的医学.
背景情况:
- 预康复干预 (运动,营养,心理支持) 在癌症手术中越来越多地被研究.
- 在过去的十年中,该领域的随机对照试验 (RCT) 显著增长.
- 需要进行全面的审查,以了解这些预康复RCT报告的结果.
研究的目的:
- 系统地描述和分析随机对照试验 (RCT) 中报告的结果,评估癌症手术患者的预康复.
- 评估报告结果的定义,测量和分类.
- 评估预康复RCT中结果报告的质量.
主要方法:
- 在多个数据库 (Embase,Cochrane,MEDLINE等) 进行了系统的文献搜索. 在2021年7月之前.
- 包括手术前运动,营养和胸部和胃肠癌手术患者的心理干预的RCT.
- 提取了字面结果,使用验证的工具评估了它们的定义和测量,并将它们分类为标准化领域.
主要成果:
- 分析了74个RCT,提取了601个字面结果;只有18.3%被定义,44.9%被指定为初级/二级.
- 手术的结果是最常见的 (95.9%的试验).
- 总体而言,结果报告质量很差 (哈曼得分的中位数为2.0),这表明存在显著的异质性.
结论:
- 癌症手术的预康复RCT显示出大量的异质性和结果报告的低质量.
- 建议制定和实施标准化的核心成果集.
- 标准化结果可以提高瘤学前康复研究的质量和临床适用性.
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