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印度的冷EM研究

Arun K Shukla, Manidipa Banerjee, Appu K Singh

Structure (London, England : 1993)

|February 2, 2024

概括

这个收藏突出显示了印度.

科学领域:

结构生物学研究结构生物学研究

背景情况:

庆祝细胞出版社50周年,还有一期关于结构生物学的特别刊物.
专注于印度冷电子显微镜 (cryo-EM) 研究的快速进展.

研究的目的:

展示印度冷EM相关研究的进展.
为印度结构生物学家的工作提供见解.
绘制全国各地可用的全国冷电磁设备的地图.

主要方法:

结构生物学家的"声音"的集合.
引入个别研究项目.
国家冷电子显微镜设施的描述.

主要成果:

汇编了印度结构生物学家的研究亮点.
关于印度冷EM现状和能力的概述.

结论:

在印度的冷EM研究领域显著增长.
强调国家设施在推进结构生物学方面的重要性.

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Cryo-electron Microscopy

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...