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基于丝蛋白的纳米孔微球,用于通过自组装在离子液体系统中可控制的药物输送
Qianqian Deng1,2, Ping Lin1,2, Hanling Gu1,2
1Center of Analysis and Testing, Nanjing Normal University, Nanjing 210023, China.
Biomacromolecules
|February 2, 2024
概括
丝纤维素 (SF) 和SF/多分子 (d,l-乳酸) 微球是使用离子液体 (IL) 制造的,用于药物输送. 这些纳米孔状载体显示出有希望的持续释放和抗癌疗效,提供可调节的药物递送动力学.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 离子液体 (ILs) 为生物医学应用提供了独特的特性.
- 丝蛋白 (SP) 和其复合物正在研究用于药物输送车辆.
- 自组装方法对于制造先进生物材料至关重要.
研究的目的:
- 使用IL诱导的自我组装方法制造和表征丝蛋白和丝蛋白/多酸) 纳米孔微球.
- 调查材料组成对药物负载,释放动力学和抗癌疗效的影响.
- 阐明影响药物输送的相互作用机制和结构变化.
主要方法:
- 通过IL诱导的自我组装制造丝蛋白和丝蛋白/多酸) 微球.
- 使用SEM,TEM,FTIR,XPS,DSC,XRD和TGA进行形态和结构表征.
- 药物加载和体外释放研究.
- 评估抗癌疗效和热稳定性.
主要成果:
- 与复合材料相比,丝蛋白微球呈现出更大的纳米孔和更高的药物负载 (88.7%).
- 复合物显示初始药物释放速度比纯丝蛋白更快 (4小时内53.5%).
- 两种配方均显示24小时后持续释放,抗癌疗效,并改善了热稳定性.
- IL诱导的自我组装涉及静电和疏水相互作用,导致可逆的蛋白质结构转变.
结论:
- 通过IL自组装制造的基于丝蛋白的纳米孔微球是有前途的药物输送工具.
- 调整丝蛋白质结构,例如通过与多,d,l-乳酸混合),可以控制药物释放动力学.
- 这些微球具有将其纳入各种生物材料的潜力,以增强治疗应用.
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