相关实验视频

Updated: Jul 4, 2025

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
08:55

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

Published on: December 14, 2017

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LRRK2激酶基质RAB8a和RAB10在人类神经元中贡献了互补但不同的疾病相关的表型

Adamantios Mamais1, Anwesha Sanyal2, Austin Fajfer1

  • 1Center for Translational Research in Neurodegenerative Disease and Fixel Institute for Neurologic Diseases, Department of Neurology, University of Florida, Gainesville, FL, USA.

Stem cell reports
|February 2, 2024
PubMed
概括

氨酸丰富的重复激酶2 (LRRK2) 的突变导致帕金森病. 这项研究使用基因编辑来表明,禁用LRRK2基质RAB8a和RAB10对神经元健康有相反的影响,为疾病机制提供了新的见解.

关键词:
这是LRRK2帕金森病 帕金森病拉布10 拉布10 拉布10在 Rab8a 里面,你会看到 Rab8a.塔乌·塔乌 (Tau Tau) 是一个这就是 iPSC 的意义.一个同核蛋白.

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Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation12:49

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

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Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate11:31

Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate

Published on: September 18, 2013

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