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Updated: Aug 3, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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微波依赖的热释放方法用于寡核酸化5'-酸化

Dominika Krygier1, Mikołaj Przybyła2, Marcin K Chmielewski1,3

  • 1Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznań, Poland.

Organic letters
|February 2, 2024
PubMed
概括

一种新的方法使用热敏触发器进行寡核酸化和净化. 该技术允许在中性条件下进行受控的酸盐回收,并通过微波辐射增强有效的降解保护.

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Nuclear Overhauser Enhancement (NOE)01:06

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Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling. This phenomenon, called the nuclear Overhauser enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring spin-active...