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通过滴滴沉积建模和注射成型来定制双层片中的药物释放

Farnoosh Ebrahimi¹, Han Xu¹, Evert Fuenmayor¹

¹PRISM Research Institute, Technological University of the Shannon, N37 HD68 Athlone, Ireland.

International journal of pharmaceutics

|February 2, 2024

概括

这项研究结合了滴滴沉积建模 (DDM) 和注射成型 (IM) 来创建个性化的双层平板电脑. 这些先进的制造技术可以为个性化医疗提供定制的药物释放配置文件.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

双层药物的传统方法提供药物释放配置文件的有限定制.
增材制造 (AM) 为先进的制药生产提供了机会.
个性化医疗需要具有量身定制的释放特征的可适应剂型.

研究的目的:

探索使用滴滴沉积建模 (DDM) 和注射成型 (IM) 进行个性化双层平板电脑的创新生产.
调查将DDM和IM结合用于定制药物释放配置文件的能力.
用这些先进的技术来评估咖啡因和偏醇配方的加工.

主要方法:

滴滴沉积建模 (DDM) 和注塑成型 (IM) 的整合,用于双层平板制造.
使用增材制造 (AM) 原则来控制药片结构和药物释放.
咖啡因和偏醇配方的加工,特别注意DDM中的粘度挑战和IM中的过度成型.

主要成果:

成功处理使用DDM和IM的咖啡因配方.
注射成型 (IM) 通过过度成型有效处理高粘度胺配方.
由DDM制造的片剂显示出基于充填百分比和多孔度的药物释放有所不同.
由于高密度结构,IM生产的药片表现出更慢,更均的药物释放.

结论:

结合DDM和IM可以克服双层药片生产的单个技术限制.
这种综合方法可以创建个性化的口服剂型,具有可调节的药物释放.
这些发现支持通过定制药物输送系统推进个性化医疗.

关键词:

通过3D打印打印3D打印.增材制造增材制造是一种增材制造.药物输送是药物输送的过程.大规模定制定制.口服药片是口服的药片个性化医疗是个性化的医疗.多种类型的药丸.

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