相关实验视频

Updated: Jul 16, 2026

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

生物活性酸盐-酸盐-希夫基复合物:一个适应pH的平台,可用于潜在的治疗应用

Ran Tao¹, Yinjuan Wang², Ning Zhang¹

¹Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, Jiangsu Province, China.

International journal of biological macromolecules

|February 2, 2024

概括

超临界流体技术被用来创建一个新型的碳甲基酸盐--p-酸-复合体. 这种响应pH的剂体表现出抗氧化,抗菌和抗生物膜的特性,显示出对食品和料添加剂的希望.

科学领域:

材料科学材料科学材料科学
绿色化学绿色化学
生物技术是生物技术.

背景情况:

超临界流体 (SCF) 技术为纳米材料合成提供一种无毒,环保和安全的方法.
在材料制备过程中,SCF技术提高了反应速度,可控性和可重复性.
基托桑衍生物因其生物相容性和功能性质而受到广泛的研究.

研究的目的:

通过超临界流体技术合成一种新型的响应pH的复合剂,使用碳甲基酸盐 (CCS), (CT),p-酸 (CA) 和ZnSO4.
描述准备好的CCS-CT-CA-Zn复合体的协调结构和形态.
评估复合物及其酸分解形式的抗氧化,抗菌和抗生物膜活性.

主要方法:

使用CO2超临界流体技术合成CCS-CT-CA-Zn复合物.
采用技术来验证协调结构 (例如,希夫基/OH) 和复合物的形态.
评估了pH响应释放,抗氧化活性,抗菌有效性和抑制*Vibrio parahaemolyticus*运动性和生物膜形成.

主要成果:

CCS-CT-CA-Zn复合体表现出良好的分散性和均性,平均尺寸为852 ± 202 nm,PdI为0.301,泽塔电位为-31 ± 6 mV.
该复合体在酸性环境中表现出有效的pH响应释放.
复合物 (DS-B) 和其酸分解形式 (DS-A) 都显示出显著的抗氧化和抗震动活性,抑制了*V. parahaemolyticus*生物膜的形成和运动.

结论:

合成的CCS-CT-CA-Zn复合物是一种有前途的pH响应剂,具有显著的抗氧化和抗菌特性.
超临界流体技术为开发这种功能复杂剂提供了一种高效和绿色的方法.
这项研究为设计天然产品衍生的抗菌-抗氧化剂为食品和料添加剂的应用奠定了基础.

关键词:

抗菌抗氧化剂抗菌抗氧化剂酸盐 - 酸盐复合物希夫基复合物希夫基复合物超临界流体的超临界流体适应pH值的剂物

更多相关视频

Preparation of Expanded Chitin Foams and their Use in the Removal of Aqueous Copper

Preparation of Expanded Chitin Foams and their Use in the Removal of Aqueous Copper

Published on: February 27, 2021

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

相关概念视频

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...