在患有直肠腺癌的患者中,瘤微环境内的免疫细胞子集的预后价值
Tao-Wei Ke1,2, Senamile Temhlanga Zwane3, Shu-Fen Chiang4
1Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.
Anticancer research
|February 2, 2024
概括
在直肠腺癌 (READ) 中量化CD3+,CD8+和CD45RO+等免疫细胞子集提供了独立的预后价值. 这些瘤透淋巴细胞 (TILs) 的较高密度与READ患者的更好的结局和减少转移相关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 结直肠腺癌 (READ) 占结直肠癌的三分之一.
- 多式疗法改善了结果,但需要患者分层.
- 预测标记对于优化 READ 治疗反应至关重要.
研究的目的:
- 在READ中评估免疫细胞子集的预后价值.
- 为了确定CD3+,CD8+和CD45RO+T细胞密度是否预测患者的结果.
- 评估免疫细胞透和临床病理特征之间的关系.
主要方法:
- 免疫组织化学被用来量化CD3+,CD8+和CD45RO+免疫细胞.
- 这项研究包括了279名READ患者.
- 分析将免疫细胞密度与预后因素和存活率相关联.
主要成果:
- 在READ中,CD3+,CD8+和CD45RO+免疫细胞子集显示出独立的预后价值.
- 更高的内免疫细胞密度与更好的预后有关.
- 增加的T细胞子集与缺少结节,淋巴血管和围神经侵入相关.
结论:
- 免疫细胞子集 (CD3,CD8,CD45RO) 是READ患者的独立预后因素.
- 瘤透淋巴细胞 (TIL) 水平与良好的生存率有关,特别是在晚期的READ中.
- 这些免疫细胞的量化有助于预测治疗反应和患者的结果.
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