可改变的风险因素的复杂相互作用影响了非洲裔美国男性前列腺癌差异的复杂相互作用
Jabril R Johnson1, Nicole Mavingire2, Leanne Woods-Burnham2
1Department of Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA, USA. jabjohnson@msm.edu.
Nature reviews. Urology
|February 2, 2024
概括
前列腺癌不成比例地影响非裔美国男性,死亡率更高. 诸如社会决定因素和饮食等可修改因素对这些种族差异的结果有着显著的贡献.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 健康差异 在健康上的差异
背景情况:
- 前列腺癌是美国男性癌症死亡的主要原因.
- 与欧洲裔美国男性相比,非洲裔美国男性的死亡率高2.5倍.
- 尽管医学进步,但前列腺癌发病率和结果仍然存在显著的种族差异.
研究的目的:
- 探索前列腺癌发病率差异背后的复杂,多因素原因.
- 确定导致前列腺癌种族差异的关键可修改的风险因素.
- 为减轻前列腺癌发病率和改善非裔美国男性治疗结果的策略提供信息.
主要方法:
- 对已确定的不可修改的风险因素 (年龄,遗传) 的审查.
- 分析证据,将可修改的风险因素与种族差异联系起来.
- 社会经济地位,教育和获得医疗保健与诊断,治疗和生存的相关性.
主要成果:
- 不能改变的因素,如年龄和遗传学起着作用.
- 可改变的因素包括健康的社会决定因素,饮食,激素和临床试验多样性是突出的贡献者.
- 低社会经济地位,教育和医疗保健的机会与较差的结果有关.
结论:
- 前列腺癌的种族差异是由复杂的因素相互作用驱动的.
- 解决可修改的风险因素对于减少非洲裔美国男性前列腺癌负担至关重要.
- 针对社会决定因素和医疗保健准入的干预措施对于改善前列腺癌生存率至关重要.
相关概念视频
Disorders of the Male Reproductive System
419
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
419
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Strategies for Assessing and Addressing Confounding
101
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
101
Surveys
14.8K
Often, psychologists develop surveys as a means of gathering data. Surveys are lists of questions to be answered by research participants, and can be delivered as paper-and-pencil questionnaires, administered electronically, or conducted verbally. Generally, the survey itself can be completed in a short time, and the ease of administering a survey makes it easy to collect data from a large number of people.
14.8K
Cancer Survival Analysis
348
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
348
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29


