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通过综合生物信息学分析识别和初步分析与膀癌进展相关的枢纽基因

Han Wang^1,2, Junjie Liu³, Yanyan Lou³

¹Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Scientific reports

|February 2, 2024

概括

这项研究确定了参与膀癌 (BC) 发展的关键基因 (CDH19,RELN,PLP1,TRIB3). 这些基因是改善膀癌预后和治疗的潜在生物标志物.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
生物信息学是一种生物信息学.

背景情况:

膀癌 (BC) 是一个重大的健康挑战.
了解BC的分子机制对于有效的治疗策略至关重要.

研究的目的:

在膀癌和正常组织之间识别差异表达基因 (DEGs).
探索枢纽基因在BC发育中的作用及其与预后和免疫治疗的关联.

主要方法:

从TCGA和GEO数据库中分析基因表达数据.
构建加权的共同表达网络和蛋白质与蛋白质相互作用 (PPI) 网络.
进行了基因本体学 (GO) 和KEGG通路丰富分析.

主要成果:

在TCGA中确定了3461个DEG,在GSE中确定了1069个DEG,其中87个基因重叠.
瘤组织中的枢纽基因与细胞增殖有关,而正常组织中的枢纽基因与神经递质合成有关.
CDH19,RELN,PLP1和TRIB3与患者预后有显著的关联 (P <0.05).

结论:

CDH19,RELN,PLP1和TRIB3都与膀癌的发展有关.
这些基因代表了BC治疗和预后的潜在生物标志物.

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