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Updated: Jul 4, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

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卡尔雷蒂库林和JAK2V617F驱动突变诱导了骨髓增殖性瘤中明显的线粒性缺陷

Kristin Holl1, Nicolas Chatain2,3, Susanne Krapp1

  • 1Institute of Biochemistry and Molecular Cell Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

Scientific reports
|February 2, 2024
PubMed
概括

骨髓增殖性瘤 (MPNs) 涉及细胞分裂中的错误. 这项研究将JAK2和CALR突变与错误的线粒分裂联系起来,这表明了对MPN发展的新理解.

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