相关实验视频

Updated: Jul 4, 2025

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

废除的分数激光治疗减少了对小鼠基底细胞癌的刺路径基因表达

Kristian Kåber Pedersen¹, Jonatan Riber Granborg¹, Catharina Margrethe Lerche^1,2

¹Department of Dermatology, Copenhagen University Hospital Bispebjerg, 2400, Copenhagen, Denmark.

Lasers in medical science

|February 2, 2024

概括

Ablative Fractional Laser (AFL) 显著降低了在小鼠基底细胞癌 (BCCs) 中的刺路径基因表达,类似于局部的vismodegib. 需要进一步的研究来探索AFL用于BCC治疗.

科学领域:

皮肤病学皮肤病学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

基础细胞癌 (BCC) 是一种常见的皮肤癌.
刺信号通路对于BCC发育至关重要.
维斯莫迪吉布是一种FDA批准的刺路径抑制剂.

研究的目的:

为了研究AFL对子路径基因表达在小鼠BCCs的影响.
为了比较AFL的效果与局部vismodegib治疗.
为了评估AFL和vismodegib的联合治疗.

主要方法:

用CO2AFL,局部vismodegib或组合治疗小鼠微观BCC.
刺路径基因表达 (Gli1,Gli2,Ptch1) 通过qPCR进行了分析.
使用液态染色体质谱测量测量了Vismodegib度.

主要成果:

一次AFL治疗显著降低了BCCs中的刺基因表达.
维斯莫迪吉布单疗法显示Gli1和Gli2表达的减少比AFL单疗法更大.
组合疗法产生了与vismodegib单一疗法相当的结果.

结论:

Ablative 分数激光单一疗法有效地降低了小鼠BCCs中的子通路基因表达.
AFL对基因表达的影响模仿了局部视的作用.
需要进一步的研究来评估AFL对BCC的治疗潜力.

关键词:

压缩式分数激光器压缩式分数激光器压缩式分数激光器基底细胞癌瘤是一种基本细胞癌.刺抑制剂刺抑制剂鼠类瘤模型的模型在Vismodegib上可以看到.

更多相关视频

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

相关概念视频

Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...