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吸入氧气水平对在小鼠大脑中增强葡萄糖的动态MRI的影响

Jianpan Huang¹, Zilin Chen², Peter C M van Zijl^3,4

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China.

Magnetic resonance in medicine

|February 2, 2024

概括

吸入氧气水平在小鼠大脑组织中的动态葡萄糖增强 (DGE) 核磁共振显著影响,在高氧化下显示较低的信号. 大脑脊髓液 (CSF) DGE MRI不受氧气水平的影响. 当DGE实验期间氧化率发生变化时,需要仔细解释.

科学领域:

神经成像是一种神经成像.
生物物理学的生物物理.

背景情况:

动态葡萄糖增强 (DGE) MRI是一种用于测量葡萄糖代谢的技术.
氧化水平可以影响磁共振成像 (MRI) 信号.

研究的目的:

为了研究吸入氧气水平对DGEMRI在3特斯拉的小鼠大脑组织和脑脊液 (CSF) 的影响.

主要方法:

从正常和高氧状态下的小鼠获得DGEMRI数据,使用在共振变量延迟多脉冲 (在VDMP) 的MRI.
在DGE获取过程中,静脉注射了D-葡萄糖玻尿酸.
磁共振光谱 (MRS) 证实了D-葡萄糖的存在.

主要成果:

与高氧化症相比,在normoxia下的大脑组织中观察到显著更高的DGE效应 (p < 0.001).
在CSF中,在normoxia和hyperoxia (p > 0.3) 之间没有发现DGE效应的显著差异.
由于缩短T1和BOLD效应,在高氧状态下基线MR组织信号的增加解释了观察到的DGE差异.

结论:

在小鼠大脑组织中,DGE MRI信号在高氧症下显著低于在正常症下.
脑脊流DGEMRI不受吸入氧气水平的影响.
由T1放松和BOLD效应影响的基线信号的变化,需要仔细解释不同氧化水平的DGE实验.

关键词:

T1放松放松的过程取决于血液氧化水平 (BOLD)大脑组织大脑组织.大脑脊髓液 (CSF) 是一种动态葡萄糖增强 (DGE) 的MRI.氧气氧气氧气氧气

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