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Updated: Jul 4, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

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CSN6-SPOP-HMGCS1轴通过YAP1激活促进肝细胞癌的进展

Kai Li1,2,3,4, Jiayu Zhang1,2,3,4, Haiwen Lyu1,2,3,4

  • 1Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 2, 2024
PubMed
概括

这项研究显示,CSN6通过稳定HMGCS1,激活YAP1.1,从而促进肝癌. 向CSN6和HMGCS1抑制瘤生长,为脂肪肝疾病相关的癌症提供了一种新的策略.

关键词:
在HFD中,HFD是指HFD.一个YAP1一个YAP1胆固醇的代谢 胆固醇的代谢肝细胞癌 (HCC) 是一种肝细胞癌.

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