与中风相关的大脑与心脏的交叉通话:病理生理学,临床影响和潜在机制
Xuehui Fan1,2,3, Jianyang Cao4,5, Mingxia Li4,5
1Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 2, 2024
概括
急性缺血性中风 (AIS) 可以导致严重的心脏问题,由于大脑心脏轴的相互作用. 了解这些机制是预防和管理中风后心血管功能障碍的关键.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 病理生理学 病理生理学
背景情况:
- 急性缺血性中风 (AIS) 显著影响心血管功能,导致心脏病发作和心力衰竭等一系列并发症.
- 脑心轴描述了中枢神经系统和心血管系统之间的双向通信,这对中风的结果至关重要.
- 了解这种相互作用对于改善患者预后和降低死亡率至关重要.
研究的目的:
- 审查目前对AIS和心血管功能障碍相关的病理生理机制的理解.
- 探索脑心轴在中风相关心脏并发症中的作用.
- 建议这些功能障碍的管理策略.
主要方法:
- 对AIS诱导的心血管功能障碍的临床前和临床研究的综述.
- 对神经幽默道的分析,包括下丘脑-垂体-上腺 (HPA) 轴,自主神经系统和炎症反应.
- 检查现有的治疗干预措施及其局限性.
主要成果:
- 通过涉及HPA轴,交感/副交感失衡,炎症和肠道失调症的机制,AIS引发心血管并发症.
- 这些因素集体影响了与中风相关的大脑心脏轴,导致不良心脏事件.
- 目前对高血压和心律失常的治疗方法存在局限性,治疗目标仍然难以捉摸.
结论:
- 大脑-心轴在AIS之后的心血管并发症中起着至关重要的作用.
- 需要进一步的研究来确定有效的治疗点来管理这些复杂的相互作用.
- 对这些机制的全面理解对于开发新型治疗策略至关重要.
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