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相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Cluster Sampling Method01:20

Cluster Sampling Method

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Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
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Survival Tree01:19

Survival Tree

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Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
 Building a Survival Tree
Constructing a...
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Phylogenetic Trees03:21

Phylogenetic Trees

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Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
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Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
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Quantifying and Rejecting Outliers: The Grubbs Test01:02

Quantifying and Rejecting Outliers: The Grubbs Test

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Sometimes, a data set can have a recorded numerical observation that greatly  deviates from the rest of the data. Assuming that the data is normally distributed, a statistical method called the Grubbs test can be used to determine whether the observation is truly an outlier.  To perform a two-tailed Grubbs test, first, calculate the absolute difference between the outlier and the mean. Then, calculate the ratio between this difference and the standard deviation of the sample. This...
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相关实验视频

Updated: Jul 4, 2025

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
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登德罗X:在登德罗图中多层次的多集群选择.

Feiling Feng1, Qiaonan Duan2, Xiaoqing Jiang1

  • 1Department of Biliary Tract Surgery I, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.

BMC genomics
|February 2, 2024
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概括

DendroX是一款用于交互式树枝图形可视化的网络应用程序,简化了热图中的集群识别. 它有助于发现具有共同生物活性的新型化合物集群,例如抗癌和抗炎作用.

关键词:
集群分析就是对集群进行分析.一个登德罗图.在LINCS L1000中使用LINCS.自然医学是一种自然医学.

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Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data
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ExCYT: A Graphical User Interface for Streamlining Analysis of High-Dimensional Cytometry Data
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Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
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Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data
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科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 数据可视化 数据可视化

背景情况:

  • 集群热图对于在生物数据中发现模式至关重要.
  • 为集群分析确定合适的树图切割是具有挑战性的.
  • 现有的工具通常需要在不同级别的集群中进行多次切割.

研究的目的:

  • 开发一个交互式Web应用程序,DendroX,用于改进树枝图形可视化和集群分析.
  • 为了促进从热图中对集群的识别和功能分析.
  • 为了解决匹配视觉和计算集群决定的困难.

主要方法:

  • 开发了DendroX,这是一个带有交互式牙图形可视化的Web应用程序.
  • 实现了从R/Python对象中提取链接矩阵的功能.
  • 创建了一个GUI用于从文本文件准备输入文件.
  • 在数万个节点的树图上测试了可扩展性.

主要成果:

  • DendroX使用户能够将任何级别的树枝图分为多个集群.
  • 一项针对297种化学化合物的案例研究确定了17个具有生物学意义的集群.
  • 发现了一组具有抗癌,抗炎和抗氧化作用的新型天然化合物.

结论:

  • DendroX有效地弥合了热图中的视觉和计算集群识别之间的差距.
  • 该工具有助于用户在复杂的树枝图结构中进行导航.
  • 确定了一组具有重大共享生物活性的天然化合物集群,这表明生物效应趋同.