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食物偏好的遗传决定因素:对观察性研究的系统审查
Jalal Hejazi1, Roksaneh Amiri2, Shadi Nozarian3
1Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
BMC nutrition
|February 2, 2024
概括
遗传变异会影响成年人对食物的偏好. 特定的基因变异与偏好甜,苦和脂肪食物以及宏观营养素摄入量有关.
科学领域:
- 营养基因组学 营养基因组学
- 人类遗传学 人类遗传学
- 行为科学 行为科学
背景情况:
- 成人的食物偏好和饮食选择受到基因型的影响.
- 关于食物偏好遗传决定因素的现有研究提出了矛盾的发现.
- 需要进行系统审查,以澄清食物偏好的遗传基础.
研究的目的:
- 系统地审查和评估成年人对食物偏好的遗传决定因素.
- 识别与食物选择和消费模式的变化相关的特定基因变异.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 搜索了关于基因型对健康成年人食物选择,偏好和摄入量影响的研究 (1994-2022).
- 使用纽卡斯尔-太华尺度评估研究质量和偏差风险.
主要成果:
- 从8,510个记录中,包括了50项研究.
- 在TAS2R38变体和苦味/甜味偏好之间发现了显著的相关性.
- 在5-HT2A受体基因多态化 (T102C) 和蛋白质摄入量,CD36 (rs1761667) 和脂肪偏好之间确定了相关性.
结论:
- 某些遗传变异与成年人的食物偏好有显著的关联.
- 本综述强调了影响饮食习惯的特定基因味觉受体相互作用.
- 进一步的研究可以利用这些发现进行个性化的营养策略.
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