密码性中风患者左心房变化指标:系统性审查和元分析
Amy Clark1,2, Aaisha Ferkh1,2, Jamie Vandenberg3,4
1Department of Cardiology, Westmead Hospital, Westmead, New South Wales, Australia.
European journal of clinical investigation
|February 3, 2024
概括
密码性中风患者表现出左心房 (LA) 大小和功能的改变,这表明潜在的心房肌病. 这一发现可能有助于对未确定的来源 (CS-ESUS) 密码性中风患者的复发性中风风险进行分层.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 源不明的密码性中风 (CS-ESUS) 缺乏明确的原因.
- 在CS-ESUS中,心房动 (AF) 是常见的,这表明左心房 (LA) 肌肉病的潜在作用.
- 在CS-ESUS中研究LA结构和功能对于理解中风病因至关重要.
研究的目的:
- 在CS-ESUS患者的LA大小和功能的改变使用心声学来调查.
- 将CS-ESUS患者的LA参数与健康对照组和其他中风组进行比较.
- 在CS-ESUS中探索LA肌病,血栓形成和心律失常之间的潜在联系.
主要方法:
- 系统的文献综述和观测研究的元分析.
- 搜索了PubMed,EMBASE,科克伦图书馆,科学网络和SCOPUS (1990-2023年) 等网站.
- 包括成年CS-ESUS患者,他们的LA测量来源于胸腔回声心电图.
主要成果:
- 包括29项研究,包括3927名CS-ESUS患者.
- 与对照组相比,CS-ESUS患者的LA体积更大,LA排空/储应变减少.
- 随后出现AF的CS-ESUS患者的LA尺寸较小,功能比没有AF的患者更好.
结论:
- 在CS-ESUS患者中,左心房的大小和功能显著改变.
- 潜在的心房肌病可能会导致CS-ESUS患者的一个子集的血栓形成和AF.
- 在CS-ESUS患者中,LA功能评估可以帮助进行复发性中风风险分层.
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