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右对左袖口位置用于上呼吸道刺激.

Alexandra M Arambula1,2, Antonio Bon-Nieves1, Rahul Alapati1

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
|February 3, 2024
PubMed
概括

这项研究发现,在左下 (L-down) 和右上 (R-up) 上呼吸道刺激 (UAS) 植入物之间,阻塞性睡眠呼吸暂停治疗结果没有显著差异. 虽然L-down植入物在初步分析中显示了更高的坚持,但在进一步的审查中没有维持这一点.

关键词:
坚持性 坚持性阻塞性睡眠呼吸暂停症是什么上空气道刺激的上空气道刺激

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科学领域:

  • 睡眠医学 睡眠医学
  • 神经外科 神经外科
  • 生物医学工程 生物医学工程

背景情况:

  • 阻塞性睡眠呼吸暂停 (obstructive sleep apnea,OSA) 是一种常见的睡眠障碍,在睡眠期间重复出现上呼吸道崩的特征.
  • 上呼吸道刺激 (UAS) 通过电气刺激下神经来维持呼吸道通透性,为OSA提供了替代治疗方法.
  • 植入物定位,特别是电极袖口方向 (L-down vs. R-up),可能会影响无人机系统的有效性和患者的治疗结果.

研究的目的:

  • 评估左侧 (L-down) 与右侧 (R-up) 上呼吸道刺激 (UAS) 电极袖口方向对阻塞性睡眠呼吸暂停患者结果的影响.
  • 为了比较L-down和R-upUAS队列之间的治疗成功,坚持和多睡眠学参数.

主要方法:

  • 追溯队列研究包括190名在2016年至2021年期间接受UAS植入的患者.
  • 患者根据X射线确认的电极袖口方向进行分类:L-down (向下方向) 或R-up (向上方向).
  • 分析使用了最近的睡眠研究变量,比较呼吸暂停-呼吸暂停指数,治疗成功,坚持和爱普沃思睡眠度量得分.

主要成果:

  • 在L-down和R-up组之间,在呼吸暂停-呼吸暂停指数的降低,治疗成功率,功能值,治疗幅度或爱普沃思嗜睡量表得分方面没有发现显著差异.
  • 在单变量分析中,L-down组的设备坚持度 (每周使用小时) 显着更高 (47.1 vs 41.0 小时/周),但在多变量分析中,这种差异没有维持.
  • 导致L向下方向的原因包括狩猎/射击,先前的辐射/手术,中枢端口和臂损伤.

结论:

  • 无人机电极袖口的方向 (L-down vs. R-up) 并没有导致阻塞性睡眠呼吸暂停患者的治疗结果有显著差异.
  • 虽然单变量分析表明L-down植入物具有更高的坚持性,但这一发现需要在更大的队列中进一步调查.
  • 需要对更大患者群体进行未来的研究,以探索电极袖口方向和UAS治疗结果之间的关系.