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糖尿病中的C-:双激素障碍中的参与者?

Ali Dakroub¹, Ali Dbouk², Aref Asfour³

¹St. Francis Hospital and Heart Center, Roslyn, New York, USA.

Journal of cellular physiology

|February 3, 2024

概括

曾经被认为是惰性的C-现在被认为是糖尿病的双重作用. 它可以防止早期糖尿病的损伤,但可以促进晚期动脉样硬化,提供新的诊断和治疗可能性.

科学领域:

内分泌学和新陈代谢学
分子生物学分子生物学
心血管研究研究心血管研究

背景情况:

胰岛素合成的副产品C-历史上被认为是生物惰性的.
新兴证据强调C-是一种多功能分子,在糖尿病病理生理学中起着重要作用.
了解C-的各种功能对于管理糖尿病及其并发症至关重要.

研究的目的:

阐明C-在糖尿病不同阶段的多面性作用.
研究C-在1型糖尿病和2型糖尿病早期 (T2DM) 的保护机制.
检查C-对晚期T2DM的有害影响及其作为生物标记物的潜力.

主要方法:

对C-的分子机制现有文献的审查.
对C-对内皮细胞,免疫细胞和血管光滑肌细胞的影响的分析.
对C-的信号通路的评估,包括AMPK,NF-kB,PI-3K和MAP激酶.

主要成果:

在T1DM和早期T2DM中,C-通过激活AMPK,减少ROS,预防亡和抑制VSMC增殖,表现出抗炎和抗原性质.
相反,在T2DM晚期,C-通过增加单细胞招募,脂质积累和VSMC增殖来促进动脉样硬化.
C-与胰岛素抵抗有关,并与T2DM冠状动脉疾病风险增加有关.

结论:

C-的作用从早期糖尿病的保护作用转变为晚期T2DM的有害作用.
补充C可以改善T1DM的末端器官损伤.
C-具有作为胰岛素耐药性和冠状动脉疾病的生物标志物,以及作为治疗点的潜力.

关键词:

动脉样硬化动脉样硬化心血管疾病心血管疾病胰岛素耐药性是一种胰岛素耐药性.代谢性疾病是代谢性疾病.血管光滑肌肉的肌肉.

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