流产的流行病学:全球负担,可变的风险因素和预测
Fei Tong1, Yue Wang2, Qianqian Gao3
1Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, China.
Human reproduction (Oxford, England)
|February 3, 2024
概括
流产发病率在全球范围内正在下降,但在某些国家正在增加. 健康不佳,吸烟和久坐不动会增加风险,而高等教育和出生体重会降低风险.
科学领域:
- 流行病学 流行病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 全球趋势和流产风险因素缺乏全面的分析.
- 以前的研究发现了一些相关因素,但得出了不一致的结论.
研究的目的:
- 分析全球趋势和疾病负担的怀孕损失从1990-2019.
- 预测到2030年的未来趋势.
- 通过使用遗传方法,识别妊娠流产的个体级风险因素.
主要方法:
- 使用的全球疾病负担 (GBD) 2019年数据用于全球趋势.
- 用于趋势预测的就业自回归集成移动平均 (ARIMA).
- 应用孟德尔随机化 (MR) 和多变量MR (MVMR) 对FinnGen联盟数据的分析.
主要成果:
- 2019年,全球发生了4239万例妊娠流产病例;发生率,DALY和死亡率呈现下降趋势 (1990-2019).
- 年龄标准化率与社会人口指数 (SDI) 有负相关性,预计到2030年将进一步下降.
- 确定了关键的风险因素:整体健康评级不佳,吸烟开始,久坐不动,教育水平较低,母亲出生体重较低.
结论:
- 在全球范围内,孕妇流产负担正在下降,根据SDI和地区存在显著差异.
- 个人风险因素包括遗传易感性,生活方式选择 (吸烟,久坐行为) 和社会经济因素 (教育,出生体重).
- 这些发现可以为公共卫生政策提供信息,以预防妊娠损失.
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