在幼儿园常见的玩具上的肠道病毒的稳定性
S N A N Baharin1, S L Tan2, I C Sam1
1Department of Medical Microbiology, Faculty of Medicine, University of Malaya.
Tropical biomedicine
|February 3, 2024
概括
手足口病 (HFMD) 病毒存在于有孔的和无孔的玩具表面. 较低的温度和更光滑的表面增加了病毒的稳定性,强调了儿童保育场所需要频繁消毒的需要.
科学领域:
- 病毒学 病毒学
- 环境科学 环境科学
- 公共卫生 公共卫生
背景情况:
- 手足口病 (HFMD) 是一种常见的儿童疾病,由肠道病毒 (如肠道病毒A71 (EV-A71)) 引起.
- 这些病毒通过直接和间接接触传播,它们在玩具等表面的稳定性对于了解幼儿园等环境中的传播至关重要.
- 玩具表面类型和环境条件可以显著影响病毒的持久性.
研究的目的:
- 对包括EV-A71在内的肠道病毒在各种多孔和无孔玩具表面上的稳定性和持久性进行研究.
- 为了确定温度和表面特性对肠道病毒生存的影响.
- 为儿童保育机构提供针对HFMD有效消毒策略的数据.
主要方法:
- 用EV-A71和其他肠道病毒在不同温度 (4°C,24°C,35°C) 中对多孔 (泡,纸张,织物,木材) 和无孔 (塑料,金属) 表面进行注射.
- 使用中位数组织培养感染剂量 (TCID50) 试验量化传染性病毒.
- 使用原子力显微镜 (AFM) 分析表面地形,以将粗度与病毒稳定性相关联.
主要成果:
- 肠道病毒在所有测试表面,包括多孔和无孔表面,都表现出持久性.
- 在较低的温度下 (4°C>24°C>35°C) 病毒的持久性显著更长.
- EV-A71的半衰期因温度而异,从0.13-12.8小时不等;光滑的,无孔的表面显示出更好的病毒稳定性.
结论:
- 幼儿园的多孔和无孔表面都可以容纳持久性肠道病毒.
- 温度和表面特征是影响肠道病毒稳定的关键因素.
- 经常消毒玩具和表面是防止HFMD在教育环境中爆发的必要条件.
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