腹部脂肪和老年人的认知能力下降之间的关联:一个为期10年的社区研究
Kazuaki Uchida1, Taiki Sugimoto2, Chikako Tange3
1Department of Prevention and Care Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan; Department of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Hyogo 654-0142, Japan.
The journal of nutrition, health & aging
|February 3, 2024
概括
腹部脂肪,包括腰围和脂肪区域,与老年人的认知能力下降有关. 脂肪水平较高的男性表现出更大的认知衰退,而女性表现出腰部和皮下脂肪水平较高的衰退.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 认知能力下降是老年人群的一个重大问题.
- 腹部脂肪是一个日益严重的健康问题,可能会产生系统性影响.
- 了解身体组成和认知健康之间的关系对于预防策略至关重要.
研究的目的:
- 为了研究腹部脂肪和随着时间的推移而改变认知功能之间的联系.
- 为了确定不同的腹部脂肪 (腰围,皮下脂肪区域,内脏脂肪区域) 是否会影响认知能力下降.
- 探索潜在的性别差异在腹部脂肪和认知能力下降之间的关系.
主要方法:
- 在社区居住的老年人 (≥60岁) 没有认知障碍的长度研究.
- 认知功能通过每两年进行一次,长达10年的迷你精神状态检查 (MMSE) 进行评估.
- 腹部脂肪通过腰围和计算机断层扫描测量皮下脂肪区域 (SFA) 和内脏脂肪区域 (VFA),按性别分层.
主要成果:
- 在男性中,更高的腰围 (WC),SFA和内脏脂肪区域 (VFA) 与MMSE得分的更大下降有关.
- 在女性中,较高的WC和SFA与较大的MMSE得分下降有关,但VFA没有显著的关联.
- 这项研究包括873名老年人,分析对性别进行了调整.
结论:
- 增加的腹部脂肪,特别是男性更高的WC,SFA和VFA,女性更高的WC和SFA,是认知能力下降的危险因素.
- 这些发现表明,腹部肥胖对认知衰退的影响可能因性别而异.
- 针对腹部脂肪的减少可能是缓解老年人认知衰退的潜在策略.
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