相关实验视频

Updated: May 3, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

智能,响应性,自组装水凝的内科应用纠正了创伤性脑损伤中氧气和能量代谢

Yuhan Han¹, Weiji Weng¹, Yongkang Zhang²

¹Brain Injury Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Head Trauma, Shanghai, China.

|February 3, 2024

概括

新的注射水凝为严重创伤性脑损伤 (TBI) 提供了有针对性的治疗. 这些智能水凝清理反应性氧物种 (ROS) 并提供2-脱氧葡萄糖 (2DG),以减少二次脑损伤并改善预后.

科学领域:

生物材料科学生物材料科学
神经科学是一个神经科学.
再生医学是一种再生医学.

背景情况:

严重创伤性脑损伤 (TBI) 管理优先考虑紧急手术,但面临着像氧化应激和代谢障碍等二次损伤机制的挑战.
传统神经保护剂的系统性输送受限于针对性差,延迟作用和不良影响,影响TBI患者的预后.

研究的目的:

开发可注射,智能,自组装的水凝 (P-RT/2DG) 用于在TBI治疗中精确的手术内应用.
研究P-RT/2DG水凝在清除活性氧物种 (ROS) 和调节能量代谢方面的双重神经保护功能.

主要方法:

P-RT/2DG水凝是通过将ROS响应性硫基甲基连接剂 (RT) 纳入聚乙烯糖醇来合成的.
这些水凝旨在降解和释放2-脱氧葡萄糖 (2DG),针对ROS和能量赤字.
进行了体外和体外研究,以评估水凝在TBI模型中的有效性和安全性.

主要成果:

P-RT/2DG水凝证明了有效的ROS清理和降解后的2DG释放,抑制TBI后的ROS-乳酸盐循环.
在体外和体内试验证实了水凝的神经保护作用,显著减少,神经元亡和神经炎症.
该研究证实了系统性副作用的缺失以及血脑屏障完整性的维持.

结论:

可注射P-RT/2DG水凝代表了一种新的治疗策略,用于精确,手术期间治疗严重的TBI.
这些智能水凝通过解决氧化应激和代谢功能障碍,有效地减轻二次脑损伤.
开发的水凝系统提供了一种有希望的方法,以提高TBI患者的结果,提高安全性和有效性.

关键词:

水凝是一种水凝.乳酸盐是一种乳酸盐.氧化应激是一种氧化应激.有反应性氧物种的反应性氧物种.创伤性脑损伤是一种创伤性脑损伤.

更多相关视频

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

相关概念视频

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

Cellular Injury I: Introduction

Cellular Injury I: Introduction

Cellular injury occurs when a cell cannot maintain homeostasis or adapt to stressors such as hypoxia, toxins, or trauma. Depending on severity and duration, injury may be reversible, allowing recovery, or irreversible, leading to cell death.General Mechanisms of Cell InjuryAlthough causes vary, most cellular injuries arise from a few key mechanisms that disrupt essential functions and often amplify one another. Cell survival depends on the extent and balance of these disturbances.ATP depletion...