应急管理加上初始可卡因戒断的接受和承诺治疗:顺序多重分配随机试验 (SMART) 的结果
Joy M Schmitz1, Angela L Stotts2, Anka A Vujanovic3
1Faillace Department of Psychiatry & Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, United States.
Drug and alcohol dependence
|February 3, 2024
概括
接受和承诺治疗 (ACT) 结合应急管理 (CM) 改善了可卡因戒断的开始. 莫达菲尼尔并没有改善非反应者的结果,这些人不太可能保持戒断.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 成 药物 药物 药物 药物
背景情况:
- 可卡因使用障碍 (CUD) 治疗需要优化戒断结果.
- 适应性干预和SMART设计可以个性化治疗阶段.
- 应急管理 (CM) 是CUD治疗的关键组成部分.
研究的目的:
- 测试一种适应性干预措施,以优化CUD中禁欲.
- 评估是否接受和承诺疗法 (ACT) 添加到CM改善了第一阶段的反应.
- 为了评估modafinil (MOD) 与安慰剂 (PLA) 的增强,对于第一阶段的非响应者.
主要方法:
- 使用了一种顺序多重分配随机试验 (SMART) 设计.
- 第一个阶段:118名参与者随机分配到ACT+CM或药物咨询 (DC+CM).
- 第2阶段:不响应者重新随机选择MOD或PLA;响应者继续治疗.
主要成果:
- 在ACT+CM (24.5%) 与DC+CM (17.5%) 之间,第一阶段的应答率更高.
- 第1阶段的响应者保持了比非响应者更高的戒断率.
- 在第2阶段,modafinil增剂没有显著影响.
结论:
- 将ACT添加到CM中可以促进可卡因戒断的开始.
- 初始治疗响应者表现出更好的持续戒断.
- 莫达菲尼尔不是有效的药物疗法,用于增强CUD非响应患者的治疗.
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