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心理健康和下尿路症状:来自NHANES和门德尔随机化研究的结果
Xiaotian Zhang1, Leilei Ma1, Jing Li1
1Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Journal of psychosomatic research
|February 3, 2024
概括
心理健康问题与较高的下尿道症状 (LUTS) 风险有关,包括尿失禁和膀过活. 这项研究表明了潜在的因果关系,强调了综合护理方法的必要性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 临床观察表明,下泌尿道症状 (LUTS) 和心理健康问题之间存在相关性.
- 确立LUTS和心理健康之间的直接因果关系仍然具有挑战性.
研究的目的:
- 调查心理健康问题与下泌尿道症状 (LUTSs) 之间的潜在因果关系.
- 为LUTSs.提供综合管理战略的证据.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2005-2018) 的横截面研究.
- 使用多变量调整后勤回归和门德尔随机化 (MR) 分析.
- 基因仪器来源于全基因组关联研究 (GWAS) 数据库.
主要成果:
- 心理健康问题与尿失禁 (OR:4.38) 和膀过活 (OR:2.31) 的风险增加有关.
- 核磁共振分析表明潜在的因果关系:抑郁症状与尿路感染 (UTI) (OR:1.005),尿路感染 (OR:1.024) 和膀过活的焦虑症状 (OR:1.017).
- 神经症与囊炎相关 (OR:1.072),排尿困难 (OR:1.001),以及尿频/尿失禁 (OR:1.001).
结论:
- 这项研究提供了证据,支持心理健康和LUTSs之间的相关性.
- 整体的方法整合身体和心理因素对于管理LUTSs至关重要.
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