溶剂极性和溶解物的疏水性是同一枚硬币的两面
Pedro P Madeira1, German Todorov2, Vladimir N Uversky3
1CICECO, Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Biochemical and biophysical research communications
|February 3, 2024
概括
对于药物分发至关重要的溶液疏水性,取决于溶液结构和水性溶剂特性. 了解这种关系可以改善化合物毒性和生物效应的预测.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 物理化学 物理化学
背景情况:
- 疏水性量化了溶解物与水性环境的相互作用.
- 水性溶剂的特性,如极性,受到成分的影响,并影响溶解物水性.
- 药物化学家经常忽视溶剂成分对溶解物水性的影响,这对药物分发至关重要.
研究的目的:
- 突出水溶剂成分在确定溶解物疏水性方面的重要性.
- 强调相对疏水性在预测药物分布和生物效应方面的作用.
- 引入水性双相系统作为估计相对疏水性的一种方法.
主要方法:
- 使用水性双相系统来分离溶解物.
- 测量各种水溶性化合物的分离行为.
- 将分区数据与溶解物疏水性和溶剂性质联系起来.
主要成果:
- 相对水性是溶液结构和水性溶剂的特定性能的函数.
- 水性两相系统分区提供了对相对疏水性的定量估计.
- 这种方法可以完善化合物毒性和生物活性的预测.
结论:
- 水性环境的组成显著影响溶解物水性.
- 在水性双相系统中使用分区来估计相对疏水性,这对于药物开发至关重要.
- 准确的疏水性评估可以提高药物分布,毒性和生物结果的预测.
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