奖励网络的异常有效连接在第一个情节的精神分裂症与听觉口头幻觉
Jingli Chen1, Yarui Wei1, Kangkang Xue1
1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China; Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, 450052, China.
Journal of psychiatric research
|February 3, 2024
概括
精神分裂症的听觉语言幻觉 (AVH) 涉及到被破坏的奖励网络连接. 具体来说,观察到右腹条纹体和腹膜区域之间的连接发生了变化,这表明AVHs的神经生物学机制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 在精神分裂症中,听觉语言幻觉 (AVH) 与半边缘皮层电路功能障碍有关.
- 在AVH的基础上确切的信息流动中断仍然不清楚.
研究的目的:
- 研究精神分裂症患者和没有AVHs的奖励网络内的神经因果相互作用.
- 使用动态因果建模 (DCM) 来量化有效连接 (EC) 差异.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于86名AVH患者 (AVH),93名无AVH患者 (NAVH) 和88名正常对照者 (NC).
- 用光谱动态因果建模 (DCM) 来分析八个奖励网络枢纽之间的连接.
- 进行了小组级分析和连接性和症状得分之间的相关性.
主要成果:
- 与NAVH患者相比,AVH患者从右腹条纹体 (RVS) 到腹肌区域 (VTA) 的EC表现较弱.
- 与对照人群相比,AVH患者从左前半岛 (AI) 到RVS,从RVS到前带状皮质 (ACC) 和从VTA到后带状皮质 (PCC) 显示出更强的EC.
- 从右AI到ACC的EC和特定症状子得分之间发现了负相关性.
结论:
- 奖励网络中的神经因果相互作用在精神分裂症中被破坏.
- 结果表明受影响的多巴胺依赖突出归因和自上而下的监测.
- 向ACC增强的 afferent通路可能代表一个补偿机制和潜在的治疗目标.
相关概念视频
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
114
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
114
Positive Symptoms Schizophrenia: Hallucinations and Delusions
57
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
57
Psychological and Sociocultural Causes of Schizophrenia
89
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
89
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
648
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
648
Biological Causes of Schizophrenia
57
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
57
Schizophrenia
80
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
80


