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在多双诱导的女性生殖毒性方面取得了进展

Chunrui Wu1, Xingde Du1, Haohao Liu1

  • 1College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.

The Science of the total environment
|February 3, 2024
PubMed
概括

聚二 (PCB) 破坏女性生殖,导致更低的怀孕率和卵巢损伤. 这些内分泌干扰化学物质 (EDC) 也导致表观遗传效应和多代生殖损害.

关键词:
流行病学研究是流行病学研究.女性生殖有毒性 女性生殖有毒性机制 机制 机制聚化双烯的多种类型毒理学研究 毒理学研究

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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