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可修改的风险因素调解了胃食道逆流病对中风和亚型的影响:孟德尔随机化研究
Shixuan Chen1, Zhenzhen Chen2, Xia Jiang1
1Department of Rehabilitation Medicine, Zhejiang University of Traditional Chinese Medicine Affiliated Wenzhou City Hospital of Integrated Western and Traditional Chinese Medicine, China.
胃食道逆流性疾病 (GERD) 与增加中风风险有因果关系. 高血压,高血压和2型糖尿病部分调解了这种关联,突出了预防中风的潜在干预目标.
科学领域:
- 心血管流行病学心血管流行病学
- 胃肠病学 胃肠病学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,胃食道逆流性疾病 (GERD) 与中风风险增加之间存在联系.
- 这种关联背后的确切机制仍然不完全理解.
研究的目的:
- 使用孟德尔随机化 (MR) 调查GERD和中风之间的因果关系.
- 探索可修改风险因素在GERD中风路径中的调解作用.
主要方法:
- 使用双样本的门德尔随机化 (MR) 与全基因组关联研究 (GWAS) 数据用于GERD.
- 检查了与中风,缺血性中风,内出血和缺血性中风亚型的关联.
- 采用两步式MR来通过15个潜在的风险因素来评估调解.
主要成果:
- 确认了基因预测的GERD与中风风险增加 (OR: 1.22),缺血性中风 (OR: 1.19) 和大动脉中风 (OR: 1.49) 之间的因果关系.
- 敏感性和复制性分析支持了这些发现.
- 高血压 (HTN),缩血压 (SBP) 和2型糖尿病 (T2D) 被确定为显著的调解者,占GERD中风效应的实质比例.
结论:
- GERD与中风,缺血性中风和大动脉中风的风险增加有关.
- 高血压,静脉压升高和2型糖尿病部分介导了GERD对中风的因果作用.
- 这些发现强调了管理GERD及其相关风险因素以减轻中风风险的重要性.
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