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Updated: Jul 30, 2026

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对于小鼠阿尔波特综合征的发展和进展而言,PDGF-D是不可或缺的

Emilia Anouk Margo Firat1, Eva Miriam Buhl2, Nassim Bouteldja1

  • 1Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.

The American journal of pathology
|February 3, 2024
PubMed
概括

血小板衍生生长因子-D (PDGF-D) 在阿尔波特综合征病中上调. 然而,抑制PDGF-D并没有改善小鼠模型中的功能或疾病标志物,这表明它不会在没有激活的情况下驱动疾病的进展.

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...