在ST段升高心肌梗塞 (STEMI) 患者中,内皮氧化合成酶 (eNOS) 基因多态化 (Glu298asp) 和氧化 (NO) 水平
Mohit Dayal Gupta1, Cherian Akkarappatty2, Shekhar Kunal3
1Department of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, India.
Indian heart journal
|February 3, 2024
概括
内皮氧化合成酶 (eNOS) 基因的遗传变异与心血管疾病有关. 在40岁以上的患者中,eNOS Glu298Asp多态性与STEMI有关,但在年轻患者中并非如此.
科学领域:
- 心血管遗传学 心血管遗传学
- 分子心脏病学分子心脏病学
- 心血管疾病的生物标志物
背景情况:
- 内皮氧化合成酶 (eNOS) 基因多态化与心血管疾病 (CVD) 有关.
- 了解遗传倾向对于评估心血管疾病风险至关重要.
研究的目的:
- 在年轻成年人中调查eNOS基因多态 (894G/T) 与ST段升高心肌梗塞 (STEMI) 之间的关联.
- 评估氧化 (NO) 水平作为STEMI患者潜在生物标志物的作用.
主要方法:
- 一项病例控制研究,涉及300名STEMI患者 (分为40岁以下的早期CAD和40岁以上的STEMI) 和300名健康对照.
- 对eNOS 894G/T多态的基因定型和对血氧化 (NO) 水平的测量.
主要成果:
- 与对照组相比,在整体患者组中,没有发现eNOS 894G/T多态和STEMI之间的显著关联.
- 在40岁以上的患者中,在894 TT基因型和STEMI之间观察到显著的关联 (OR=2.5,P=0.047).
- 与健康对照组相比,在40岁以上的STEMI患者中检测到较低的血NO度 (P=0.001).
结论:
- 在40岁以上的患者中,eNOS Glu298Asp多态性与STEMI显著相关.
- 在早发冠状动脉疾病患者 (<40岁) 中没有观察到这种关联.
- 老年STEMI患者的NO水平降低可能表明其作为心血管疾病生物标志物的潜力.
相关概念视频
Nitric Oxide Signaling Pathway
5.0K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.0K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
92
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
92
Antianginal Drugs: Nitrates and β-Blockers
592
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
592


