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在非潜水员中,一系列重复的静态和动态呼吸暂停之后,压力生物标志物发生变化
Antonis Elia1, Matthew J Barlow2, Matthew J Lees3
1Division of Environmental Physiology, KTH Royal Institute of Technology, Stockholm, Sweden.
Respiratory physiology & neurobiology
|February 3, 2024
概括
重复的最大动态呼吸暂停会导致肌肉损伤,与静态呼吸暂停不同,但不会引起心脏或神经元损伤. 这项研究使用压力生物标志物评估了在呼吸炼后的生理应变.
科学领域:
- 身体生理学 身体生理学
- 运动医学 运动医学
- 生物化学 生物化学
背景情况:
- 呼吸暂停,或呼吸暂停,在自由潜水等运动中很常见.
- 了解最大静态 (STA) 和动态 (DYN) 呼吸暂停的生理应变对于运动员的安全至关重要.
- 生物标志物可以表明生理压力和潜在的伤害.
研究的目的:
- 量化来自重复最大静态和动态呼吸暂停的生理应变.
- 根据这些协议,评估特定的与压力相关的生物标志物.
- 为了比较DYN,STA和对照 (CTL) 协议对生理标记的影响.
主要方法:
- 十一名健康的男性接受了三个方案:最大STA,最大DYN和CTL (静态呼吸).
- 每个方案都在不同的场合进行,会议之间至少有72小时的时间.
- 血液样本被分析为缺血症修饰性白蛋白 (IMA),神经元特异性酶 (NSE),肌球蛋白,和高灵敏性心脏素T (hscTnT) 在30分钟,90分钟和180分钟后的协议.
主要成果:
- 缺血症修饰性白蛋白 (IMA) 在STA和DYN呼吸暂停后显著增加,在DYN之后更明显的升高.
- 肌球蛋白水平在DYN后30分钟显著升高,表明肌肉损伤,并且在DYN后比STA和CTL更高.
- 没有观察到神经元特异性乙醇酶 (NSE) 或高灵敏性心脏托罗素T (hscTnT) 的显著变化,这表明没有心肌或神经元损伤.
结论:
- 重复的最大动态呼吸暂停会比静态呼吸暂停引起更大的肌肉损伤.
- 无论是静态的还是动态的最大呼吸暂停协议都没有导致心肌损伤.
- 在任何一种类型的呼吸暂停后都没有发现神经元-副体损伤的证据.
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