手术前的酒精使用,术后的疼痛和冠状动脉绕道手术后的阿片类药物使用
D Keegan Stombaugh1, Karen Singh1, Amir Malek1
1University of Virginia, Department of Anesthesiology, Charlottesville, VA.
Journal of cardiothoracic and vascular anesthesia
|February 3, 2024
概括
术前的酒精消费,即使在较高水平,也没有显著影响早期的术后疼痛或阿片类药物的使用在接受冠状动脉旁路移植 (CABG) 的患者. 这项研究发现,在心脏手术后,酒精摄入量和急性疼痛管理之间没有明确的联系.
科学领域:
- 心脏病学 心脏病学
- 麻醉学 麻醉学
- 成 药物 药物 药物 药物
背景情况:
- 慢性酒精使用与慢性疼痛和增加阿片类药物需求有关.
- 酒精消费与急性术后疼痛之间的关系尚不清楚.
- 冠状动脉旁路移植 (CABG) 患者代表了一个患有显著的术后疼痛和阿片类药物需求的人群.
研究的目的:
- 为了研究术前酒精消费水平与术后疼痛之间的关联.
- 为了确定手术前的酒精使用和CABG手术后的阿片类药物消费之间的关系.
- 为CABG患者提供有关疼痛管理策略的见解,这些患者的酒精摄入量各不相同.
主要方法:
- 追溯队列研究的设计.
- 包括在单个学术医疗中心接受隔离CABG的患者.
- 对人口统计,并发症和自我报告的每周酒精消费情况的分析.
主要成果:
- 不同的酒精消费群体在术后0天的平均疼痛得分没有显著差异 (p=0.66).
- 在术后0天的中位数吗啡毫克相当量 (MME) 使用量之间,在饮酒组之间没有显著差异 (p=0.14).
- 分析包括1338名患者,按每周酒精摄入量进行分类:没有,≤1饮料,2-7饮料和≥8饮料.
结论:
- 轻度至中度的术前酒精消费没有明显与早期术后疼痛的关联.
- 在手术前使用酒精似乎不会影响CABG患者早期的阿片类药物需求.
- 研究结果表明,酒精消费模式可能不是CABG后急性疼痛或阿片类药物使用的主要决定因素.
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