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妊娠期糖尿病通过破坏孕产妇免疫力和阴道微生物群来增加B组链球菌感染

Vicki Mercado-Evans^1,2, Marlyd E Mejia¹, Jacob J Zulk¹

¹Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA.

Nature communications

|February 3, 2024

概括

孕期糖尿病 (GDM) 通过增加子宫内传播和改变孕产妇免疫力和微生物群来加剧B组链球菌 (GBS) 周产期疾病. 这项研究确定了导致GDMGBS并发症的关键宿主和细菌因素.

科学领域:

周产期微生物学周产期微生物学
母胎免疫学母胎免疫学
微生物组研究的研究.

背景情况:

乙组链球菌 (GBS) 是围产期感染的主要原因.
影响GBS在子宫传播的因素尚不清楚.
孕期糖尿病 (GDM) 与增加GBS风险有关.

研究的目的:

调查GDM如何影响GBS传播和围产期结果.
在GDM模型中识别参与GBS病变的宿主和细菌因素.
探索母亲免疫和微生物变化在GBS传播中的作用.

主要方法:

利用GDM和GBS殖民/传播的小鼠模型.
采用双RNA测序来分析GBS适应和宿主反应.
评估了子宫免疫细胞群 (例如NK细胞) 和细胞因子 (cytokine) 概况.
与GDM和GBS状态相关的阴道微生物群落的特征.

主要成果:

在GDM小鼠中,GBS在子宫内扩散的增加和新生儿结果较差.
GBS在GDM生殖道中表现出特定的适应,包括改变的基因表达 (例如,yfhO).
GDM与子宫NK细胞激活减少,胎盘招募受损以及母胎细胞因子改变有关.
在GDM和GBS感染的小鼠中观察到明显的阴道微生物特征.

结论:

通过增强传播和改变宿主免疫力,GDM会加剧GBS周产期疾病.
在GDM中,特定的细菌适应和宿主免疫失调有助于GBS的发病.
母亲的微生物组与GDM和GBS侵袭性疾病有关,这表明存在复杂的相互作用.

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