南美洲ACE I / D多态的频率:系统性审查和元分析
Rebeca Gonçalves Trevisano1, Helen Matias1, Thais de Jesus Teani2
1Department of Obstetrician, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Molecular and cellular biochemistry
|February 3, 2024
概括
这就是ACE I/D多态.
科学领域:
- 遗传学和分子生物学
- 心血管研究研究心血管研究
- 人口健康 人口健康
背景情况:
- ангиотензин转化酶 (ACE) 对于血压调节至关重要.
- 关于南美ACE I/D多态频率和相关表型的数据有限.
- 了解这些变化对于特定人群的健康洞察至关重要.
研究的目的:
- 确定南美ACE I/D多态的等位体和基因型频率.
- 研究ACE I/D基因型与各种疾病和健康状况的关联.
- 基于对最近文献的系统审查,提供全面的概述.
主要方法:
- 系统审查过去25年发表的研究.
- 在多个主要科学数据库 (PubMed,Scielo,LILACS等) 进行的搜索. ) 的情况.
- 包括121项研究,使用STREGA指南进行质量评估.
主要成果:
- 基因型的发生频率:DD (32.1%),ID (47.4%),II (20.5%).
- 相关疾病包括高血压,心血管疾病,呼吸系统问题,癌症和代谢障碍.
- 显著的大多数研究 (61.1%) 发现ACE I/D多态和研究条件之间没有显著的关联.
结论:
- 在南美人口中,ACE I/D 多态表现出不同的频率.
- 虽然研究了与多种疾病的关联,但大多数研究报告的发现并不显著.
- 可能需要进一步的研究来澄清ACE I/D多态化在特定南美卫生环境中的作用.
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