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对20 086个已故捐赠者的肝脏活检进行了当代分析

Benjamin K Wang¹, Alyssa Y Chen¹, Jai Prasadh¹

¹Department of Surgery, Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

World journal of surgery

|February 3, 2024

概括

根据风险分层的已故捐赠者的肝脏活检在接受者结果中没有显著差异. 一些带有纤维化或肥胖症的活检肝脏可能适合移植,这可能会减少器官浪费.

科学领域:

肝病学肝病学是一种肝病学.
移植医学移植医学
器官采购器官采购

背景情况:

对于已故供体肝脏的移植前活检解释因中心而异.
为了优化器官利用,需要标准化解释.

研究的目的:

评估已故供体肝脏活检风险分层对移植利用和受体结局的影响.
识别目前被拒绝的潜在可用的捐赠肝脏.

主要方法:

在2015年1月4日至2020年1月12日期间通过UNOS STARfile.确定的成年接受者.
供体肝脏活检根据纤维化,脂肪化和炎症分为低,中和和高风险组.
移植利用率,捐赠者风险概况和接受者结果 (停留时间,移植存活率) 在风险组之间进行比较.

主要成果:

移植肝脏的脂肪,纤维化和门浸透比非移植肝脏的肝脏少.
在高风险和低风险活检组之间,移植后停留时间或1年移植存活率没有显著差异.
五年移植存活率在风险层之间没有差异.
26.0%的活检和拒绝肝脏被认为是潜在可用的.

结论:

已故的捐赠人肝脏有一些纤维化,炎症或肥胖症 (≥30%) 可能适合移植.
对这些移植的进一步调查可能会降低器官转移的速度.

关键词:

活组织活检纤维化纤维化这是一种炎症炎症炎症炎症.肝脏肝脏肝脏肝脏肝脏肝脏危险的风险危险的风险蒸汽症 (steatosis) 是一种疾病.

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