使用ICOSL抗体的干预缓解了中性喘小鼠的炎症透
Heting Dong1, Yinying Ren1,2, Yiyi Song3
1Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou 215003, China.
Iranian journal of immunology : IJI
|February 4, 2024
概括
在中性性喘小鼠模型中,用抗体阻断诱导性T细胞共刺激器连接体 (ICOSL) 减少了呼吸道炎症和粘液. 这表明ICOSL封锁是这种疾病的有希望的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 中性喘是由气道中显著的中性粒细胞透来定义的.
- 了解驱动中性友性喘的机制对于开发有效治疗方法至关重要.
研究的目的:
- 在中性友性喘的小鼠模型中研究抗ICOSL抗体的治疗疗效.
- 评估ICOSL阻塞对呼吸道炎症和免疫反应的影响.
主要方法:
- 在雌性BALB/c小鼠中使用卵胺和脂多糖化合物诱导了中性喘.
- 小鼠接受了抗ICOSL,控制IgG或没有治疗.
- 分析了细胞因子水平,支气管洗液 (BALF) 细胞计数和肺组织学.
主要成果:
- 抗ICOSL治疗显著减少了中性粒细胞透和BALF的炎症细胞.
- IL-6,IL-13和IL-17的水平下降,而IFN-γ在BALF和血中增加.
- 肺炎,粘液分泌和ICOSL表达因抗ICOSL治疗而减少.
结论:
- 阻断ICOS/ICOSL通路有效地改善了中性喘患者的肺炎和粘液产生.
- 观察到Th1/Th2/Th17平衡的恢复,表明ICOSL封锁的免疫调节作用.
- 准ICOSL代表了管理中性友性喘的潜在治疗方法.
相关概念视频
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
298
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
298
Drugs Used in Lower Respiratory Disorders: Overview
442
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
442


