酒精消费对多发性硬化症的影响使用基于模型的标准化和错误分类通过概率偏差分析进行调整
Pooneh Malekifar1, Saharnaz Nedjat1, Ibrahim Abdollahpour2
1Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Archives of Iranian medicine
|February 4, 2024
概括
这项研究表明,饮酒增加了患多发性硬化症 (MS) 的风险. 调整偏差证实了饮酒和MS发病率之间的积极因果关系.
科学领域:
- 流行病学 流行病学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 的确切原因尚不清楚.
- 评估酒精消费等风险因素因混和测量偏差而复杂化.
研究的目的:
- 为了确定酒精消费对MS的因果关系.
- 为了调整自我报告的酒精摄入量和混因素的错误分类偏差.
主要方法:
- 基于人群的事件病例控制研究,包括547名多发性硬化症患者和1057名对照.
- 用于识别混因素的因果定向非循环图.
- 概率偏差分析方法 (PBAM) 和基于模型的标准化 (MBS) 用于调整偏差和估计因果效应.
主要成果:
- 对酒精消费和多发性硬化症的调整后风险比率在1.93至2.02之间.
- 人口归因分数 (PAF) 在0.15和0.17之间.
- 风险差异为0.0001.1. 这就是风险差异.
结论:
- 饮酒对多发性硬化症的发病率产生了积极的因果关系.
- 调整了测量偏差,混和随机错误的结果.
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