乳腺癌哨兵淋巴结检测率:第一个大规模的多中心数据技术花酸盐
Ramesh Omranipour1,2, Mehrshad Abassi3, Newsha Nazarian4
1Breast Disease Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
Archives of Iranian medicine
|February 4, 2024
概括
酸在乳腺癌患者的哨兵淋巴结活检中显示出高检测率. 这种放射性药物无论在手术当天或前一天注射是否有效,为股分期提供了一个可行的选择.
科学领域:
- 在瘤学瘤学.
- 核医学就是核医学.
- 手术病理学手术病理学
背景情况:
- 哨兵淋巴结活检 (SLNB) 是乳腺癌股分期的标准.
- 放射性药物如Technetium (Tc) 合物在全球范围内使用,检测率达到94%.
- 由于当地生产容易,TC酸盐在伊朗被使用,但其大规模检测率不太了解.
研究的目的:
- 为了评估SLNB的检测率,使用Tc酸盐.
- 评估Tc酸盐在SLNB中的优缺点.
- 分析Tc植物酸盐在乳腺癌分期中的疗效的多中心数据.
主要方法:
- 追溯性,横截面,多中心研究设计.
- 包括接受SLNB与Tc酸盐治疗的乳腺癌患者.
- 检测率的计算和注射时间的比较 (手术前一天 vs 手术前一天).
主要成果:
- 包括2663名女性;总体检测率为91.8%.
- 假阴性率为8.2%.
- 在手术当天或手术前一天注射的检测率在统计学上相似 (P=0.32).
结论:
- 在乳腺癌中,tc酸对无线电引导SLNB的检测率很好.
- 注射时间 (手术前一天或一天) 并没有显著影响结果.
- 在乳腺癌分期中,tc植物酸是SLNB的可行的放射性药物.
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